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Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors

14 Jul 2015

Abstract excerpt

OBJECTIVES: The spread of MDR bacteria represents a serious threat to human society and novel antibiotic drugs, preferably from new chemical classes, are urgently needed. Closthioamide was isolated from the strictly anaerobic bacterium Clostridium cellulolyticum and belongs to a new class of natural products, the polythioamides. Here, we investigated the antimicrobial activity and mechanism of action of...

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PMID: 26174721
DOI: 10.1093/jac/dkv161

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