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Article

Heat stress alters the virulence of a rifampin-resistant mutant of Francisella tularensis LVS.

Infection and immunity - 1 Jan 1995

Bhatnagar N B, Elkins K L, Fortier A H

Abstract excerpt

We have studied the stress response of a rifampin-resistant mutant of Francisella tularensis LVS. This mutant, Rif 7, was avirulent with an intraperitoneally administered 50% lethal dose greater than 10(7) CFU in a murine model of infection. Exposure of Rif 7 to heat stress for 5 h in vitro resulted in a 2-log decrease in its 50% lethal dose (P < 0.02). The increase in virulence was dependent on the time of...

Topics

Animals
Drug Resistance, Microbial
Francisella tularensis
Hot Temperature
Liver
Macrophages, Peritoneal
Mice
Mutation
Rifampin
Spleen
Stress, Physiological
Virulence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7806352
DOI: 10.1128/iai.63.1.154-159.1995
PMCID: PMC172972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7806352-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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