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Article

Heat stress alters the virulence of a rifampin-resistant mutant of Francisella tularensis LVS.

Infection and immunity - 1 Jan 1995

Bhatnagar N B, Elkins K L, Fortier A H

Abstract excerpt

We have studied the stress response of a rifampin-resistant mutant of Francisella tularensis LVS. This mutant, Rif 7, was avirulent with an intraperitoneally administered 50% lethal dose greater than 10(7) CFU in a murine model of infection. Exposure of Rif 7 to heat stress for 5 h in vitro resulted in a 2-log decrease in its 50% lethal dose (P < 0.02). The increase in virulence was dependent on the time of...

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Source

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Identifiers

PMID: 7806352
DOI: 10.1128/iai.63.1.154-159.1995
PMCID: PMC172972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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