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Article

Changes in proteome of the Δhfq strain derived from Francisella tularensis LVS correspond with its attenuated phenotype.

Proteomics - 1 Nov 2014

Lenco Juraj, Tambor Vojtech, Link Marek, Klimentova Jana, Dresler Jiri, Peterek Miroslav, Charbit Alain, Stulik Jiri

Abstract excerpt

The posttranscriptional regulatory protein Hfq was shown to be an important determinant of the stress resistance and full virulence in the dangerous human pathogen Francisella tularensis. Transcriptomics brought rather limited clues to the precise contribution of Hfq in virulence. To reveal the molecular basis of the attenuation caused by hfq inactivation, we employed iTRAQ in the present study and compared...

Topics

Francisella tularensis
Gene Deletion
Host Factor 1 Protein
Humans
Mass Spectrometry
Phenotype
Proteome
Tularemia
Virulence Factors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25156581
DOI: 10.1002/pmic.201400198

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SRM

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