Article
EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice.
Molecular microbiology - 1 Mar 2014
Ma Zhuo, Banik Sukalyani, Rane Harshita, Mora Vanessa T, Rabadi Seham M, Doyle Christopher R, Thanassi David G, Bakshi Chandra Shekhar, Malik Meenakshi
Abstract excerpt
Francisella tularensis is a category A biodefence agent that causes a fatal human disease known as tularaemia. The pathogenicity of F. tularensis depends on its ability to persist inside host immune cells primarily by resisting an attack from host-generated reactive oxygen and nitrogen species (ROS/RNS). Based on the ability of F. tularensis to resist high ROS/RNS levels, we have hypothesized that additional...
Topics
- Amino Acid Sequence
- Animals
- Anti-Bacterial Agents
- Antioxidants
- Bacterial Proteins
- Bacterial Secretion Systems
- Drug Resistance, Bacterial
- Francisella tularensis
- Genome, Bacterial