Intracellular biology and virulence determinants of<i>Francisella tularensis</i>revealed by transcriptional profiling inside macrophages

Abstract excerpt

Summary The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen, whose virulence requires proliferation inside host cells, including macrophages. Here we have performed a global transcriptional profiling of the highly virulent F. tularensis ssp. tularensis Schu S4 strain during its intracellular cycle within primary murine macrophages, to characterize its intracellular...

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