Article
A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.
Infection and immunity - 1 Dec 2005
Twine Susan, Byström Mona, Chen Wangxue, Forsman Mats, Golovliov Igor, Johansson Anders, Kelly John, Lindgren Helena, Svensson Kerstin, Zingmark Carl, Conlan Wayne, Sjöstedt Anders
Abstract excerpt
Francisella tularensis subsp. tularensis (type A) strain SCHU S4 is a prototypic strain of the pathogen that is highly virulent for humans and other mammals. Its intradermal (i.d.) 50% lethal dose (LD50) for mice is <10 CFU. We discovered a spontaneous mutant, designated FSC043, of SCHU S4 with an i.d. LD50 of >10(8) CFU. FSC043 effectively vaccinated mice against challenge with a highly virulent type A strain,...
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