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Article

Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS).

DNA and cell biology - 1 Jul 2008

Sammons-Jackson Wendy L, McClelland Karen, Manch-Citron Jean N, Metzger Dennis W, Bakshi Chandra Shekhar, Garcia Emilio, Rasley Amy, Anderson Burt E

Abstract excerpt

Francisella tularensis is a zoonotic bacterium that must exist in diverse environments ranging from arthropod vectors to mammalian hosts. To better understand how virulence genes are regulated in these different environments, a transcriptional response regulator gene (genome locus FTL0552) was deleted in F. tularensis live vaccine strain (LVS). The FTL0552 deletion mutant exhibited slightly reduced rates of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18613792
DOI: 10.1089/dna.2007.0687
PMCID: PMC2980773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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