Article
Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS).
DNA and cell biology - 1 Jul 2008
Sammons-Jackson Wendy L, McClelland Karen, Manch-Citron Jean N, Metzger Dennis W, Bakshi Chandra Shekhar, Garcia Emilio, Rasley Amy, Anderson Burt E
Abstract excerpt
Francisella tularensis is a zoonotic bacterium that must exist in diverse environments ranging from arthropod vectors to mammalian hosts. To better understand how virulence genes are regulated in these different environments, a transcriptional response regulator gene (genome locus FTL0552) was deleted in F. tularensis live vaccine strain (LVS). The FTL0552 deletion mutant exhibited slightly reduced rates of...
Topics
- Animals
- Bacterial Vaccines
- Cells, Cultured
- Cytokines
- Female
- Francisella tularensis
- Genes, Bacterial
- Inflammation Mediators
- Macrophages
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL