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Article

Reversal of multi‐drug resistance in human KB cell lines by structural analogs of verapamil

15 May 1990

Abstract excerpt

Several structural analogs of verapamil were studied for their ability to reverse multi-drug resistance (MDR) in human KB cell lines. D595, D792 and verapamil completely reversed resistance to colchicine and adriamycin. D595 and D792 had a higher reversing potency than verapamil. Devapamil, gallopamil, emopamil and D528 partially reversed MDR. The reversing potency of a drug did not correlate with its calcium...

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PMID: 2335394
DOI: 10.1002/ijc.2910450523

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