Article
Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line.
International journal of cancer - 28 Jul 1995
Bennis S, Ichas F, Robert J
Abstract excerpt
We studied the restoration of doxorubicin accumulation and sensitivity by verapamil and quinine in a variant of the human erythroleukemia cell line K562 selected for resistance to doxorubicin and presenting a multidrug-resistance (MDR) phenotype. Verapamil was able to completely restore doxorubic...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Affinity Labels
- Azides
- Dihydropyridines
- Doxorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Drug Synergism
- Humans
- Kinetics
- Leukemia, Erythroblastic, Acute
- Microscopy, Confocal
- Microscopy, Fluorescence
- Phenotype
- Quinine
- Subcellular Fractions
- Tumor Cells, Cultured
- Verapamil