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Article

Rational design and pre-clinical pharmacology of drugs for reversing multidrug resistance

1 Jan 1992

Abstract excerpt

Drugs that interfere with the action of P-glycoprotein (P-gp), the membrane efflux pump responsible for multidrug resistance (MDR), should be valuable in the treatment of patients with drug-resistant cancer. We have used one class of drug, the phenothiazines, to study the structural features required for optimum interference with the function of P-gp. The structure-activity relationships revealed three important...

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PMID: 1346493
DOI: 10.1016/0006-2952(92)90667-8

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