Article
Effect of tamoxifen on the multidrug-resistant phenotype in human breast cancer cells: isobologram, drug accumulation, and M(r) 170,000 glycoprotein (gp170) binding studies.
Cancer research - 15 Jan 1994
Leonessa F, Jacobson M, Boyle B, Lippman J, McGarvey M, Clarke R
Abstract excerpt
We have performed isobologram analyses of the ability of tamoxifen (TAM) to alter the response to Adriamycin (ADR) and vinblastine (VBL) in human breast cancer cells. MCF-7 cells express functional receptors for estrogen and progesterone but do not express detectable levels of M(r) 170,000 glycop...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Azides
- Breast Neoplasms
- Carrier Proteins
- Dihydropyridines
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Interactions
- Drug Resistance
- Female
- Humans
- Membrane Glycoproteins
- Phenotype
- Tamoxifen
- Tumor Cells, Cultured
- Vinblastine