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Article

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

The Journal of cell biology - 18 Oct 2010

Malureanu Liviu, Jeganathan Karthik B, Jin Fang, Baker Darren J, van Ree Janine H, Gullon Oliver, Chen Zheyan, Henley John R, van Deursen Jan M

Abstract excerpt

Cdc20 is an activator of the anaphase-promoting complex/cyclosome that initiates anaphase onset by ordering the destruction of cyclin B1 and securin in metaphase. To study the physiological significance of Cdc20 in higher eukaryotes, we generated hypomorphic mice that express small amounts of this essential cell cycle regulator. In this study, we show that these mice are healthy and not prone to cancer despite...

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Identifiers

PMID: 20956380
DOI: 10.1083/jcb.201003090
PMCID: PMC2958469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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