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Article

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Cai S Y, Babbitt R W, Marchesi V T

Abstract excerpt

A new ubiquitin-processing protease (Ubp-M) has been identified in mammalian cells that is phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The carboxyl-terminal domain of this 823-aa protein can be phosphorylated in vitro with either extracts of mitotic cells or purified cdc-2/cyclin B complexes. Recombinant Ubp-M is able to deubiquitinate histone H2A in...

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Identifiers

PMID: 10077596
DOI: 10.1073/pnas.96.6.2828
PMCID: PMC15854

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