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Article

Novel Role of Base Excision Repair in Mediating Cisplatin Cytotoxicity

1 Mar 2011

Abstract excerpt

Using isogenic mouse embryonic fibroblasts and human cancer cell lines, we show that cells defective in base excision repair (BER) display a cisplatin-specific resistant phenotype. This was accompanied by enhanced repair of cisplatin interstrand cross-links (ICLs) and ICL-induced DNA double strand breaks, but not intrastrand adducts. Cisplatin induces abasic sites with a reduced accumulation in uracil DNA...

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PMID: 21357694
DOI: 10.1074/jbc.m111.225375

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