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Article

Quasispecies of hepatitis C virus and genetic drift of the hypervariable region in chronic type C hepatitis.

The Journal of infectious diseases - 1 Jul 1995

Kao J H, Chen P J, Lai M Y, Wang T H, Chen D S

Abstract excerpt

The sequential variations of amino acid sequences in the hypervariable region (HVR)-1 of hepatitis C virus (HCV) and changes of viremia in 2 patients with different clinicopathologic courses of chronic hepatitis C were studied. By using polymerase chain reaction amplification, cloning, and sequencing of HVR-1, genetic heterogeneity of HCV was shown. The highest annual rate of consensus amino acid variation per...

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Identifiers

PMID: 7797927
DOI: 10.1093/infdis/172.1.261

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