Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer.

Gastroenterology - 1 Jul 1995

Jacoby R F, Marshall D J, Kailas S, Schlack S, Harms B, Love R

Abstract excerpt

BACKGROUND & AIMS: Genetic instability related to defective DNA mismatch repair genes may be involved in the pathogenesis of carcinoma in hereditary nonpolyposis colon cancer (HNPCC). However, nonneoplastic tissues from patients inheriting defects in human MSH2 or human MLH1 do not show significant genetic instability. The aim of this study was to determine whether acquisition of genetic instability at the...

Topics

Adenoma
Adult
Aged
Carcinoma
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA, Neoplasm
DNA, Satellite
Female
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Identifiers

PMID: 7797042
DOI: 10.1016/0016-5085(95)90270-8

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7797042-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer.PMID 7797042Read ↗

Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.Semantic proximity Read ↗

Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum.Semantic proximity Read ↗

DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.Semantic proximity Read ↗

Hereditary non-polyposis colorectal cancer--morphologies, genes and mutations.Semantic proximity Read ↗

Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.Semantic proximity Read ↗

Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines.Semantic proximity Read ↗

The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

Microsatellite Instability in Adenomas as a Marker for Hereditary Nonpolyposis Colorectal CancerSemantic proximity Read ↗

Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

Microsatellite instability in human solid tumors.Semantic proximity Read ↗

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.