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Article

Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.

The American journal of pathology - 1 Jun 2002

Kuismanen Shannon A, Moisio Anu-Liisa, Schweizer Pascal, Truninger Kaspar, Salovaara Reijo, Arola Johanna, Butzow Ralf, Jiricny Josef, Nyström-Lahti Minna, Peltomäki Päivi

Abstract excerpt

The colorectum and uterine endometrium are the two most commonly affected organs in hereditary nonpolyposis colon cancer (HNPCC), but the genetic basis of organ selection is poorly understood. As tumorigenesis in HNPCC is driven by deficient DNA mismatch repair (MMR), we compared its typical consequence, instability at microsatellite sequences, in colorectal and endometrial cancers from patients with identical...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12057899
DOI: 10.1016/S0002-9440(10)61144-3
PMCID: PMC1850838

Genes

BAX
MLH1
MSH2
MSH3
PTEN
MLH3
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability.PMID 12057899Read ↗

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Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumorsSemantic proximity Read ↗

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Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.Semantic proximity Read ↗

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