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Article

Hereditary non-polyposis colorectal cancer--morphologies, genes and mutations.

Mutation research - 1 Oct 1994

Jass J R, Stewart S M, Stewart J, Lane M R

Abstract excerpt

Mutations in a human homologue of the yeast DNA mismatch repair gene MSH2 (equivalent to bacterial MutS) cause the condition hereditary non-polyposis colorectal cancer (HNPCC). Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Adenomas are clonal and each may serve as a...

Topics

Adenoma
Adult
Aged
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Female
Humans
Male
Middle Aged
Mutation
Nucleic Acid Heteroduplexes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7523876
DOI: 10.1016/0027-5107(94)90016-7

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7523876-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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