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Article

Hereditary non-polyposis colorectal cancer--morphologies, genes and mutations.

Mutation research - 1 Oct 1994

Jass J R, Stewart S M, Stewart J, Lane M R

Abstract excerpt

Mutations in a human homologue of the yeast DNA mismatch repair gene MSH2 (equivalent to bacterial MutS) cause the condition hereditary non-polyposis colorectal cancer (HNPCC). Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Adenomas are clonal and each may serve as a marker of a single initiating mutation. The progression of adenomas is marked by increasing size, dysplasia and...

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Source

Identifiers

PMID: 7523876
DOI: 10.1016/0027-5107(94)90016-7

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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