Article
Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum.
Gut - 1 Jul 2000
Jass J R, Iino H, Ruszkiewicz A, Painter D, Solomon M J, Koorey D J, Cohn D, Furlong K L, Walsh M D, Palazzo J, Edmonston T B, Fishel R, Young J, Leggett B A
Abstract excerpt
AIM: Colorectal cancer has been described in association with hyperplastic polyposis but the mechanism underlying this observation is unknown. The aim of this study was to characterise foci of dysplasia developing in the polyps of subjects with hyperplastic polyposis on the basis of DNA microsatellite status and expression of the DNA mismatch repair proteins hMLH1, hMSH2, and hMSH6. MATERIALS AND METHODS: The...
Topics
- Aged
- Colon
- Colorectal Neoplasms
- DNA Repair
- DNA, Neoplasm
- Disease Progression
- Female
- Humans
- Hyperplasia
- Intestinal Polyps
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation