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Article

Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer.

Cancer genetics and cytogenetics - 1 Apr 2002

Planck Maria, Halvarsson Britta, Pålsson Eva, Hallén Magnus, Ekelund Mats, Pålsson Birger, Baldetorp Bo, Nilbert Mef

Abstract excerpt

The majority of tumors from patients affected by hereditary nonpolyposis colorectal cancer (HNPCC) exhibit a mutator phenotype characterized by widespread microsatellite instability (MSI) and somatic mutations in repeated sequences in several cancer-associated genes. An inverse relationship between MSI and chromosomal instability (CIN) has been demonstrated and HNPCC-associated tumors are generally characterized...

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Share to Colonic Neoplasms
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Share to MutL Protein Homolog 1

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Share to Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 11996796
DOI: 10.1016/s0165-4608(01)00587-8

Genes

BAX
MLH1
MSH3
MSH6
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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