Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis.

Human molecular genetics - 15 Jan 2005

Alazzouzi Hafid, Domingo Enric, González Sara, Blanco Ignacio, Armengol Manel, Espín Eloi, Plaja Alberto, Schwartz Simó, Capella Gabriel, Schwartz Simó

Abstract excerpt

Microsatellite instability (MSI) characterizes tumors arising in patients with hereditary non-polyposis colorectal cancer (HNPCC) syndrome. HNPCC is a hereditary autosomal dominant disease caused by germline mutations in genes from the DNA (MMR) mismatch repair system. In these tumors, the loss of MMR compromises the genome integrity, allowing the progressive accumulation of mutations and the establishment of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Proteins

Share to Proteins

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 15563510
DOI: 10.1093/hmg/ddi021

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low levels of microsatellite instability characterize MLH1 and MSH2 HNPCC carriers before tumor diagnosis.PMID 15563510Read ↗

Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening.Semantic proximity Read ↗

High throughput detection of microsatellite instability by denaturing high-performance liquid chromatography.Semantic proximity Read ↗

Spectrum and frequencies of mutations inMSH2 andMLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancerSemantic proximity Read ↗

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: genetic reclassification and correlation with clinical features.Semantic proximity Read ↗

MSI-testing in hereditary non-polyposis colorectal carcinoma (HNPCC).Semantic proximity Read ↗

Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers.Semantic proximity Read ↗

Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines.Semantic proximity Read ↗

Microsatellite instability in the peripheral blood leukocytes of HNPCC patients.Semantic proximity Read ↗

Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.Semantic proximity Read ↗

BAT-26 identifies sporadic colorectal cancers with mutator phenotype: a correlative study with clinico-pathological features and mutations in mismatch repair genes.Semantic proximity Read ↗

Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing.Semantic proximity Read ↗

Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.