Article
Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines.
Experimental cell research - 1 Jun 1995
Jupe E R, Liu X T, Kiehlbauch J L, McClung J K, Dell'Orco R T
Abstract excerpt
Experiments were performed to determine whether prohibitin, an evolutionarily conserved gene with antiproliferative activity, has a role in cellular immortalization. A cell proliferation assay was used to examine one human cell line from each of four established immortal complementation groups, termed A, B, C, and D, and a normal human diploid fibroblast line. Only normal and Group B cells were inhibited from...
Topics
- Alleles
- Cell Division
- Cell Line, Transformed
- Fibroblasts
- Gene Dosage
- Homozygote
- Humans
- Prohibitins
- Protein Biosynthesis
- Proteins
- RNA, Messenger
- Repressor Proteins