Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with <i>p</i>53 alteration and a high frequency of allele loss

Abstract excerpt

Many human tumors contain variant cells that, unlike their normal counterparts, possess indefinite proliferative potential in vitro. However, little is known of the relevance of these immortal cells to human carcinomas in vivo. To investigate immortality in a human tumor system, we established cultures from different stages of head and neck squamous carcinoma (SCC-HN). All the neoplastic cultures were transformed...

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