Article
Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1996
Jupe E R, Liu X T, Kiehlbauch J L, McClung J K, Dell'Orco R T
Abstract excerpt
The evolutionarily conserved prohibitin gene is located on human chromosome 17q21, and two alleles have been identified. Our previous studies characterizing prohibitin in immortalized cells, classified into four complementation groups (A-D) based on the ability of whole-cell hybrids to become senescent, have suggested that it has tumor suppressor activity in group B cells. Only the cell lines assigned to group B...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.