Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.

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Article

Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jul 1996

Jupe E R, Liu X T, Kiehlbauch J L, McClung J K, Dell'Orco R T

Abstract excerpt

The evolutionarily conserved prohibitin gene is located on human chromosome 17q21, and two alleles have been identified. Our previous studies characterizing prohibitin in immortalized cells, classified into four complementation groups (A-D) based on the ability of whole-cell hybrids to become sen...

Topics

Alleles
Breast Neoplasms
Cell Division
Female
Gene Expression Regulation, Neoplastic
Genetic Linkage
Humans
Mutation
Prohibitins
Proteins
Repressor Proteins
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8809404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8809404-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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