Article
The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer.
European journal of obstetrics, gynecology, and reproductive biology - 1 Apr 2008
Grimm Christoph, Polterauer Stephan, Zeillinger Robert, Tempfer Clemens, Sliutz Gerhard, Reinthaller Alexander, Hefler Lukas A
Abstract excerpt
OBJECTIVE: Prohibitin is an important antiproliferative protein inhibiting cell proliferation by blocking the G1/S transition of the cell cycle. Recent findings indicate that the presence of at least one mutant allele within a certain prohibitin gene polymorphism causes inactivation of bioactive RNA resulting in the loss of its pro-apoptotic function and a subsequent risk for malignant growth. Based on these...
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