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The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.

Cancer research - 15 Mar 1992

Sato T, Saito H, Swensen J, Olifant A, Wood C, Danner D, Sakamoto T, Takita K, Kasumi F, Miki Y

Abstract excerpt

A gene called "prohibitin" was isolated as a candidate antiproliferating gene in rat liver cells. We have isolated the human homologue of the rat prohibitin gene and mapped it to chromosome 17q12-21 where a gene responsible for hereditary breast cancer was localized. DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm of chromosome 17 or...

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PMID: 1540973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.PMID 1540973Read ↗

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Immunohistochemical expression and mutation study of Prohibitin gene in Indian female breast cancer cases.Semantic proximity Read ↗

Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.Semantic proximity Read ↗

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Tumor suppression by the prohibitin gene 3'untranslated region RNA in human breast cancer.Semantic proximity Read ↗

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Relationship between the prohibitin 3' untranslated region C > T gene polymorphism and cancer susceptibility--results of a meta-analysis.Semantic proximity Read ↗

Prohibitin and the senescent phenotype.Semantic proximity Read ↗

Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines.Semantic proximity Read ↗

Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region.Semantic proximity Read ↗

Evidence for involvement of BRCA1 in sporadic breast carcinomas.Semantic proximity Read ↗

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