Article
The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.
Cancer research - 15 Mar 1992
Sato T, Saito H, Swensen J, Olifant A, Wood C, Danner D, Sakamoto T, Takita K, Kasumi F, Miki Y
Abstract excerpt
A gene called "prohibitin" was isolated as a candidate antiproliferating gene in rat liver cells. We have isolated the human homologue of the rat prohibitin gene and mapped it to chromosome 17q12-21 where a gene responsible for hereditary breast cancer was localized. DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm of chromosome 17 or...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Female
- Genes, Suppressor
- Humans
- Molecular Sequence Data
- Mutation