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Article

Prohibitin and the senescent phenotype.

Experimental gerontology - 1 Jan 2000

Dell'Orco R T, McClung J K, Jupe E R, Liu X T

Abstract excerpt

Prohibitin is an evolutionarily conserved gene that has antiproliferative activity, is ubiquitously expressed, and appears to be essential for cell survival. The gene codes for a 30 kD, post-synthetically modified protein located primarily in the mitochondria. It functionally inhibits cell cycle traverse and DNA synthesis, but its mechanism of action is presently unknown. Prohibitin is proposed to be a member of...

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PMID: 8706794
DOI: 10.1016/0531-5565(95)02009-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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