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Article

p57KIP2 expression and loss of heterozygosity during immortal conversion of cultured human mammary epithelial cells.

Cancer research - 15 Oct 1999

Nijjar T, Wigington D, Garbe J C, Waha A, Stampfer M R, Yaswen P

Abstract excerpt

We have uncovered a novel role for the cyclin-dependent kinase inhibitor, p57KIP2, during the immortalization of cultured human mammary epithelial cells (HMECs). HMECs immortalized after chemical carcinogen exposure initially expressed little or no telomerase activity, and their telomeres continued to shorten with passage. Cell populations whose mean terminal restriction fragment (TRF) length declined to < or = 3...

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PMID: 10537284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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