Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor suppression by the prohibitin gene 3'untranslated region RNA in human breast cancer.

Cancer research - 1 Sept 2003

Manjeshwar Sharmila, Branam Dannielle E, Lerner Megan R, Brackett Daniel J, Jupe Eldon R

Abstract excerpt

Prohibitin is a candidate tumor suppressor gene located on human chromosome 17q21, a region of frequent loss of heterozygosity in breast cancers. We showed previously that microinjection of RNA encoded by the prohibitin gene 3'untranslated region (3'UTR) blocks the G(1)-S transition causing cell cycle arrest in several human cancer cell lines, including MCF7. Two allelic forms (C versus T) of the prohibitin 3'UTR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Prohibitins

Share to Protein Biosynthesis

Share to Repressor Proteins

Share to RNA, Neoplasm

Share to Transgenes

Source

Identifiers

PMID: 14500355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor suppression by the prohibitin gene 3'untranslated region RNA in human breast cancer.PMID 14500355Read ↗

Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.Semantic proximity Read ↗

The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer.Semantic proximity Read ↗

The 3' untranslated region of prohibitin and cellular immortalization.Semantic proximity Read ↗

Relationship between the prohibitin 3' untranslated region C > T gene polymorphism and cancer susceptibility--results of a meta-analysis.Semantic proximity Read ↗

Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population.Semantic proximity Read ↗

Association of 758 G/A polymorphism of 3'untranslated region of prohibitin with risk of gastric cancer.Semantic proximity Read ↗

The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.Semantic proximity Read ↗

Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines.Semantic proximity Read ↗

Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo.Semantic proximity Read ↗

The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation.Semantic proximity Read ↗

Absence of prohibitin gene mutations in human epithelial ovarian tumors.Semantic proximity Read ↗

Deletion in a (T)8 microsatellite abrogates expression regulation by 3'-UTR.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.