Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implications of the p53 tumor-suppressor gene in clinical oncology.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 1995

Chang F, Syrjänen S, Syrjänen K

Abstract excerpt

PURPOSE: The p53 gene encompasses 16 to 20 kb of DNA on the short arm of human chromosome 17. It encodes for a 393-amino acid nuclear phosphoprotein involved in cell-cycle control. Loss of normal p53 function is associated with cell transformation in vitro and development of neoplasms in vivo. During the past few years, the dramatic progress in the molecular biology of p53 has raised the exciting prospect for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cell Cycle
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Mutation

Share to Neoplasms

Share to Prognosis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7707100
DOI: 10.1200/JCO.1995.13.4.1009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implications of the p53 tumor-suppressor gene in clinical oncology.PMID 7707100Read ↗

The p53 tumor suppressor gene as a common cellular target in human carcinogenesis.Semantic proximity Read ↗

p53 signaling in cancer progression and therapySemantic proximity Read ↗

The p53 tumor suppressor gene: from molecular biology to clinical investigation.Semantic proximity Read ↗

The role of p53 in human cancer.Semantic proximity Read ↗

Tumor-suppressor p53: implications for tumor development and prognosis.Semantic proximity Read ↗

Clinical implications of p53 mutations.Semantic proximity Read ↗

Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies.Semantic proximity Read ↗

Clinical implications of the p53 tumor-suppressor gene.Semantic proximity Read ↗

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies.Semantic proximity Read ↗

Strategies for manipulating the p53 pathway in the treatment of human cancer.Semantic proximity Read ↗

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.Semantic proximity Read ↗

P53 in cancer: a paradigm for modern management of cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.