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Article

Implications of the p53 tumor-suppressor gene in clinical oncology.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 1995

Chang F, Syrjänen S, Syrjänen K

Abstract excerpt

PURPOSE: The p53 gene encompasses 16 to 20 kb of DNA on the short arm of human chromosome 17. It encodes for a 393-amino acid nuclear phosphoprotein involved in cell-cycle control. Loss of normal p53 function is associated with cell transformation in vitro and development of neoplasms in vivo. Du...

Topics

Biomarkers, Tumor
Cell Cycle
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Mutation
Neoplasms
Prognosis
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7707100
DOI: 10.1200/JCO.1995.13.4.1009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7707100-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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