Article
P53 gene mutations: case study of a clinical marker for solid tumors.
Seminars in oncology - 1 Jun 2002
Liu Minetta C, Gelmann Edward P
Abstract excerpt
P53 is a tumor-suppressor gene that codes for a multifunctional DNA-binding protein involved in cell cycle arrest, DNA repair, differentiation, and apoptosis. The P53 gene is mutated in approximately 50% of human cancers and in germline DNA of families with inherited cancer syndromes. The role of P53 mutations in the program of carcinogenic genetic alterations differs among tumor sites ranging from the earliest...
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