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Article

Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.

Journal of virology - 1 Nov 1995

Mylin L M, Bonneau R H, Lippolis J D, Tevethia S S

Abstract excerpt

Simian virus 40 large tumor (T) antigen contains three H-2Db-restricted (I, II/III, and V) and one H-2Kb-restricted (IV) cytotoxic T lymphocyte (CTL) epitopes. We demonstrate that a hierarchy exists among these CTL epitopes, since vigorous CTL responses against epitopes I, II/III, and IV are detected following immunization of H-2b mice with syngeneic, T-antigen-expressing cells. By contrast, a weak CTL response...

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Identifiers

PMID: 7474076
DOI: 10.1128/JVI.69.11.6665-6677.1995
PMCID: PMC189576

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Source receipt: pubmed, retrieved 7 Sept 2026.

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