Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.

doi:10.1128/JVI.69.11.6665-6677.1995

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Article

Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen.

Journal of virology - 1 Nov 1995

Mylin L M, Bonneau R H, Lippolis J D, Tevethia S S

Abstract excerpt

Simian virus 40 large tumor (T) antigen contains three H-2Db-restricted (I, II/III, and V) and one H-2Kb-restricted (IV) cytotoxic T lymphocyte (CTL) epitopes. We demonstrate that a hierarchy exists among these CTL epitopes, since vigorous CTL responses against epitopes I, II/III, and IV are detected following immunization of H-2b mice with syngeneic, T-antigen-expressing cells. By contrast, a weak CTL response...

Topics

Amino Acid Sequence
Animals
Antigens, Polyomavirus Transforming
Binding Sites
Cell Line
Cytotoxicity, Immunologic
Epitopes
Genetic Variation
H-2 Antigens
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis

Mutagenesis, Site-Directed

Recombinant Proteins

Sequence Deletion

Simian virus 40

T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 7474076
DOI: 10.1128/JVI.69.11.6665-6677.1995
PMCID: PMC189576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7474076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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