Article
T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity.
Journal of virology - 1 Jan 1994
Horwitz M S, Yanagi Y, Oldstone M B
Abstract excerpt
Following infection of the H-2d mouse by lymphocytic choriomeningitis virus, the newly generated cytotoxic T lymphocyte (CTL) response is focused to a single 9-amino-acid peptide sequence (epitope) of the virus. More than 96% of the primary, secondary, and clonal CTL respond to this lymphocytic c...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Viral
- Base Sequence
- Clone Cells
- Epitopes
- Genetic Variation
- H-2 Antigens
- Immunodominant Epitopes
- Lymphocytic choriomeningitis virus
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Oligopeptides
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes, Cytotoxic