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Article

The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2000

Peshavaria M, Cissell M A, Henderson E, Petersen H V, Stein R

Abstract excerpt

PDX-1 is a homeodomain transcription factor whose targeted disruption results in a failure of the pancreas to develop. Mutations in the human pdx-1 gene are linked to an early onset form of non-insulin-dependent diabetes mellitus. PDX-1 binds to and transactivates the promoters of several physiol...

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Identifiers

PMID: 11117522
DOI: 10.1210/mend.14.12.0563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11117522-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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