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Article

Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans.

The Biochemical journal - 1 Aug 2005

Sharma Sanjeev K, Leinemann Ulrike, Ratke Regine, Oetjen Elke, Blume Roland, Dickel Corinna, Knepel Willhart

Abstract excerpt

The pancreatic islet hormone glucagon stimulates hepatic glucose production and thus maintains blood glucose levels in the fasting state. Transcription factors of the Foxa [Fox (forkhead box) subclass A; also known as HNF-3 (hepatocyte nuclear factor-3)] family are required for cell-specific activation of the glucagon gene in pancreatic islet alpha-cells. However, their action on the glucagon gene is poorly...

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Identifiers

PMID: 15828872
DOI: 10.1042/BJ20050334
PMCID: PMC1180734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans.PMID 15828872Read ↗

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