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Article

Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.

Molecular and cellular biology - 1 Sept 2010

Raum Jeffrey C, Hunter Chad S, Artner Isabella, Henderson Eva, Guo Min, Elghazi Lynda, Sosa-Pineda Beatriz, Ogihara Takeshi, Mirmira Raghavendra G, Sussel Lori, Stein Roland

Abstract excerpt

MafA is a key transcriptional activator of islet beta cells, and its exclusive expression within beta cells of the developing and adult pancreas is distinct among pancreatic regulators. Region 3 (base pairs -8118 to -7750 relative to the transcription start site), one of six conserved 5' cis domains of the MafA promoter, is capable of directing beta-cell-line-selective expression. Transgenic reporters of region 3...

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Identifiers

PMID: 20584984
DOI: 10.1128/MCB.01396-09
PMCID: PMC2937551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.PMID 20584984Read ↗

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