Article
Transcription factors recognizing overlapping C1-A2 binding sites positively regulate insulin gene expression.
The Journal of biological chemistry - 5 Jan 2001
Harrington R H, Sharma A
Abstract excerpt
Transcription factors binding the insulin enhancer region, RIPE3b, mediate beta-cell type-specific and glucose-responsive expression of the insulin gene. Earlier studies demonstrate that activator present in the beta-cell-specific RIPE3b1-binding complex is critical for these actions. The DNA binding activity of the RIPE3b1 activator is induced in response to glucose stimulation and is inhibited under glucotoxic...
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