Article
The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005
Ritz-Laser Beate, Mamin Aline, Brun Thierry, Avril Isabelle, Schwitzgebel Valérie M, Philippe Jacques
Abstract excerpt
Gene inactivation studies have shown that members of the Gata family of transcription factors are critical for endoderm development throughout evolution. We show here that Gata-4 and/or Gata-6 are not only expressed in the adult exocrine pancreas but also in glucagonoma and insulinoma cell lines, whereas Gata-5 is restricted to the exocrine pancreas. During pancreas development, Gata-4 is expressed already at...
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