Species-specific polymorphism in the promoter of the apolipoprotein A-I gene: restoration of human transcriptional efficiency by substitution at positions -189, -144 and -48 bp.

Abstract excerpt

Previous studies indicate that species-specific differences in apolipoprotein A-I (apo A-I) expression could be largely explained by cis-acting factors located within or near the 5' flanking region (-231 to +223 bp, where +1 is the start site of transcription). In the present studies, we have localized 7 sites within the (-231 to -15 bp) region of the African green monkey apo A-I gene that differ from the human...

Topics

• Animals
• Apolipoprotein A-I
• Base Composition
• Base Sequence
• Cell Line
• Chlorocebus aethiops
• Gene Expression Regulation
• Humans
• Luciferases
• Molecular Sequence Data
• Mutation