Article
Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene.
The Journal of clinical investigation - 15 Apr 1997
Naganawa S, Ginsberg H N, Glickman R M, Ginsburg G S
Abstract excerpt
To understand the factors contributing to the synthesis of human apolipoprotein AI (apoAI), relative apoAI synthesis was measured from endoscopic biopsy samples obtained from 18 healthy volunteers. The relative amount of apoAI synthesis was directly correlated with steady state intestinal apoAI m...
Topics
- Adult
- Alleles
- Apolipoprotein A-I
- Apolipoprotein C-III
- Apolipoproteins C
- Base Sequence
- Caco-2 Cells
- DNA
- DNA Primers
- Enhancer Elements, Genetic
- Genotype
- Haplotypes
- Heterozygote
- Homozygote
- Humans
- Intestinal Mucosa
- Linkage Disequilibrium
- Male