Article
Transcription efficiency of human apolipoprotein A-I promoter varies with naturally occurring A to G transition.
FEBS letters - 8 Jun 1992
Tuteja R, Tuteja N, Melo C, Casari G, Baralle F E
Abstract excerpt
In human, the gene coding for apolipoprotein A-I (apo A-I), a protein of the plasma lipid transport system, is expressed only in the liver and the intestine. A naturally occurring A to G substitution in the promoter at position -78 was shown to be associated with high density lipoproteins (HDL) in females. We have studied the effect of this mutation on promoter activity using various lengths of promoter sequences...
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