Article
A polymorphism (G-->A transition) in the -78 position of the apolipoprotein A-I promoter increases transcription efficiency.
The Journal of biological chemistry - 1 Jul 1994
Angotti E, Mele E, Costanzo F, Avvedimento E V
Abstract excerpt
AG-->A transition at -78 base pairs from the transcription start site of the apolipoprotein A-I (apoA-I) gene has been associated with increased apoA-I serum levels in humans. We report here that this mutation (G-->A) increases significantly (5-7-fold) the expression of a reporter gene fused to t...
Topics
- Adenine
- Apolipoprotein A-I
- Base Sequence
- Guanine
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Point Mutation
- Polymorphism, Genetic
- Promoter Regions, Genetic