Article
A polymorphism (G-->A transition) in the -78 position of the apolipoprotein A-I promoter increases transcription efficiency.
The Journal of biological chemistry - 1 Jul 1994
Angotti E, Mele E, Costanzo F, Avvedimento E V
Abstract excerpt
AG-->A transition at -78 base pairs from the transcription start site of the apolipoprotein A-I (apoA-I) gene has been associated with increased apoA-I serum levels in humans. We report here that this mutation (G-->A) increases significantly (5-7-fold) the expression of a reporter gene fused to the apoA-I promoter in human liver and intestine cells. In addition, the presence of A at -78 base pairs from the...
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