Article
Characterization of the promoter elements required for hepatic and intestinal transcription of the human apoB gene: definition of the DNA-binding site of a tissue-specific transcriptional factor.
Molecular and cellular biology - 1 Jun 1990
Kardassis D, Hadzopoulou-Cladaras M, Ramji D P, Cortese R, Zannis V I, Cladaras C
Abstract excerpt
The promoter elements important for intestinal and hepatic transcription of the human apoB gene have been localized downstream of nucleotide -150. Footprinting analysis using hepatic nuclear extracts identified four protected regions, -124 to -100, -97 to -93, -86 to -33, and +33 to +52. Gel elec...
Topics
- Apolipoproteins B
- Base Sequence
- Binding Sites
- Cell Line
- Cell Nucleus
- Chloramphenicol O-Acetyltransferase
- DNA
- Genes
- Humans
- Intestinal Mucosa
- Liver
- Methylation
- Molecular Sequence Data
- Mutation