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Article

Evolutionary Silencing of the Human Elastase I Gene (ELA1)

1 Jun 1997

Abstract excerpt

The human pancreatic elastase I gene is transcriptionally silent, despite the apparent integrity of the structural gene. The transcriptional regulatory sequences necessary and sufficient for transcription of the active rat homologue are localized within 205 base pairs (bp) of the transcriptional start and comprise a pancreas-specific transcriptional enhancer of 134 bp immediately upstream of a 71 bp non-specific...

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PMID: 9175736
DOI: 10.1093/hmg/6.6.897

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