Article
Species-specific regulation of the alpha-2(I) procollagen gene by proximal promoter elements.
IUBMB life - 1 Jan 2000
Leaner Virna D, Masemola Agatha, Parker M Iqbal
Abstract excerpt
Transcriptional regulation of the human alpha 2(I) procollagen proximal promoter involves the interaction of trans-acting factors at the inverted CCAAT box (G/CBE) located at position -80 and an adjacent GGAGGCCC-box at -70. Both these elements have previously been shown to be essential for activity of the human promoter. This study investigated nucleotide differences at three sites (-74, -72 and -71) between the...
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