Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study.

doi:10.1212/wnl.45.6.1092

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Article

Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study.

Neurology - 1 Jun 1995

Jarvik G P, Wijsman E M, Kukull W A, Schellenberg G D, Yu C, Larson E B

Abstract excerpt

OBJECTIVE: The joint effects of total cholesterol (TC) levels and the APOE genotype in Alzheimer's disease (AD) were evaluated because of previous reports that the APOE locus epsilon 4 allele was associated with both late-onset AD and elevated TC. DESIGN: Logistic regression was used to determine...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Case-Control Studies
Cholesterol
Female
Genotype
Humans
Male
Sex Characteristics

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