Article
Cell type-dependent modulation of the dominant negative action of human mutant thyroid hormone beta 1 receptors.
Molecular medicine (Cambridge, Mass.) - 1 Mar 1995
Wong R, Zhu X G, Pineda M A, Cheng S Y, Weintraub B D
Abstract excerpt
BACKGROUND: Mutations in the ligand-binding domain of the thyroid hormone receptor beta (TR beta) gene cause the syndrome of resistance to thyroid hormone (RTH). The clinical phenotype results from the antagonism of the normal TR alpha and the non-mutated TR beta alleles by the TR beta 1 mutants, via a dominant negative effect. There is, however, marked heterogeneity of organ resistance within and among kindreds...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- DNA Probes
- Gene Expression Regulation
- Genes, Dominant
- HeLa Cells
- Humans
- Mice
- Molecular Sequence Data
- Mutation