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Article

Mutational analysis of a putative polyphosphoinositide binding site in phospholipase C-beta 2.

FEBS letters - 29 May 1995

Simões A P, Camps M, Schnabel P, Gierschik P

Abstract excerpt

The phosphatidylinositol 4,5-bisphosphate (PtdIns-P2)-regulated actin-binding protein gelsolin and most phosphoinositide-specific phospholipases C (PLCs) comprise a basic amino acid motif ((K/R)xxxKxK(K/R); x denotes any amino acid) which was previously suggested to represent a PtdInsP2-binding site commonly present in these proteins. We have challenged this hypothesis for PLC beta 2 by replacing one or several...

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PMID: 7781770
DOI: 10.1016/0014-5793(95)00464-k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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