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Article

Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes.

The Journal of cell biology - 23 Dec 2002

Sciorra Vicki A, Rudge Simon A, Wang Jiyao, McLaughlin Stuart, Engebrecht JoAnne, Morris Andrew J

Abstract excerpt

Phospholipase D (PLD) generates lipid signals that coordinate membrane trafficking with cellular signaling. PLD activity in vitro and in vivo is dependent on phosphoinositides with a vicinal 4,5-phosphate pair. Yeast and mammalian PLDs contain an NH2-terminal pleckstrin homology (PH) domain that has been speculated to specify both subcellular localization and regulation of PLD activity through interaction with...

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Identifiers

PMID: 12486109
DOI: 10.1083/jcb.200205056
PMCID: PMC2173982

Genes

PLD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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