Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.

doi:10.1016/s0092-8674(01)00326-9

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Article

Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.

Cell - 4 May 2001

Tsujishita Y, Guo S, Stolz L E, York J D, Hurley J H

Abstract excerpt

Inositol polyphosphate 5-phosphatases are central to intracellular processes ranging from membrane trafficking to Ca(2+) signaling, and defects in this activity result in the human disease Lowe syndrome. The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate reveals a fold and an active site His and Asp pair resembling...

Topics

Amino Acid Sequence
Binding Sites
Calcium
Catalytic Domain
Cloning, Molecular
Crystallography, X-Ray
Enzyme Inhibitors
Humans
Inositol Phosphates
Inositol Polyphosphate 5-Phosphatases
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nerve Tissue Proteins

Phosphoric Monoester Hydrolases

Phosphorylation

Protein Conformation

Protein Folding

Source

Open in PubMed

Identifiers

PMID: 11348594
DOI: 10.1016/s0092-8674(01)00326-9

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